POC
◆POC (miscarriage chorion chromosome test)
Human cells contain a total of 46 chromosomes of paternal and maternal origin. Chromosome aneuploidy that occurs prior to implantation can cause miscarriage or difficulty in continuing a pregnancy; the POC test examines fetal tissue after miscarriage to determine chromosome aneuploidy in those who have experienced repeated miscarriages or are undergoing assisted reproductive technology.
It is estimated that 15-20% of human pregnancies result in miscarriage, and the rate is as high as 1 in 5-6, especially among young people. The primary cause is an "accidental" numerical chromosomal abnormality, which is not associated with disease or genetic disorders. However, in the case of repeat miscarriages, there may be other causes than accidental errors.
Miscarriage chorionic staining (POC) is performed as a means of identifying the cause of repeat miscarriages. POC provides important information for future treatment planning.
◆Benefits of POC testing
- Identifying Chromosomal Aneuploidy and Understanding Spontaneous Conception
Fifty percent of spontaneous pregnancies are due to chromosomal aneuploidy, and this abnormality can be identified through POC testing.
Miscarriages due to chromosomal aneuploidy are known to increase up to 60% in those undergoing assisted reproductive treatment. - Identifying the cause of the miscarriage and determining the course of treatment
POC testing with fetal-derived tissue provides a means of clarifying the cause of the miscarriage.
Identifying the cause of the miscarriage is especially important for those who have experienced repeated miscarriages or are undergoing assisted reproductive technologies.
If the cause of the miscarriage can be identified, this information is important in determining the specific course of future treatment. - High test result accuracy and rapid result acquisition
The POC test is expected to have a higher accuracy of test results (>99%) than conventional methods.
Results are also available approximately two weeks earlier than with conventional methods, enabling rapid diagnosis.
POC testing is a very useful method for identifying the cause of miscarriage due to chromosomal abnormalities and developing a precise treatment plan based on that identification.
◆Test results and treatment progression
- If the fetus has no numerical chromosomal abnormalities
The cause of the miscarriage may be maternal, and the mother's side is examined.
If the cause is also on the uterine side, other tests are considered. - If the fetus has a numerical chromosomal abnormality
In this case, no specific examination is required and the patient can proceed to the next stage of treatment.
If the miscarriage is due to a chromosomal abnormality, the same treatment plan is considered. - If there is a structural chromosomal abnormality
If both spouses undergo chromosome testing and structural abnormalities are present, PGT-A (Preimplantation Diagnosis) is indicated.
If there is a genetic factor, consider genetic counseling.
